Though this is definitely not a book to be taken word for word, and it definitely takes a lot of effort and talking A LOT, I would say most guys that are dating out there could learn something from this, if anything not to make stuff a big deal or to freak out over things like calling a girl and all those unspoken dating rules.
Basically, if you talk a lot, say interesting things, you can probably get most average girls. For the really beautiful ones, you have to employ a few tactics.
Honestly, I'm not sure what to think about Mystery himself or those that really put in the effort to become pickup artists. There's probably a point where they become interesting guys and not just sleazy liars that are playing you. It's fun for a girl not to have to make an effort in making the experience fun, just being there for a ride and having someone along that always has something to say, some fun story and knows what next fun place to be at. Even if he's always negging you, making you jump through hoops, conditionally testing you, or giving IODs so that you're strung along. I'm looking forward to reading this other book in the pickup artist world: The Game by Neil Strauss. Apparently, Mystery is one crazy mofo (I suppose this is probably unsurprising) and it's like a documentary of pickup artists and their lifestyles.
Mostly, I'm glad I'm not a guy and am not about to delve into trying to become good at picking up hot chicks. It sounds like a LOT of work, memorization, rejection, and feeling stupid and like a loser. Though if I was already a guy that was desperate and I actually saw some improvements, maybe it wouldn't be so crushing. And you have to talk ALL THE TIME. However, if I ever meet someone who is actually out there practicing opening sets and such, I'm not sure what I'd do, if I'd purposefully try to f-him-up or go along with it or tell him that I'm on to him and that he's gaming. So yeah, I really hope I meet a pickup artist in training someday because it would be supremely interesting to see one actually at work.